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PFT’s Week 6 2025 NFL picks: Florio vs. Simms

PFT’s Week 6 2025 NFL picks: Florio vs. Simms

Last week was challenging for many NFL fans, especially for analysts Mike Florio and Chris Simms from Pro Football Talk (PFT). With a disappointing record of 4-10 straight up and 6-8 against the spread, Florio faced a notable decline in his earlier lead over Simms, now reduced from a nine-game advantage to just a two-game edge. As of Week 6, Florio holds a record of 51-26-1 straight up and 44-34 against the spread, while Simms stands at 49-28-1 straight up and 39-39 against the spread.

Key Matchups for Week 6

This week features an exciting slate of matchups that promise to impact both the playoff race and betting lines significantly. Both analysts have shared their predictions and insights on several high-profile games. Here’s an in-depth look at those matchups.

Eagles (-7) at Giants

The Philadelphia Eagles are on a short week after a lackluster performance. Florio believes that the Eagles’ offense needs to find its rhythm. He predicts a score of Eagles 24, Giants 13, while Simms is slightly more optimistic for the Eagles with a prediction of 27-17.

Broncos (-7.5) vs. Jets (London)

Having struggled in recent games, the Denver Broncos recognize this game as a crucial opportunity to earn a win against a Jets team that has been racked by losses. Each analyst is aligned in picking the Broncos, with Florio predicting a decisive 28-9 victory, while Simms sees the score at 28-13.

Rams (-7.5) at Ravens

The Ravens have struggled significantly this season, prompting Florio to question their resilience. He projects a Rams win of 30-13, while Simms is more confident in the Rams, offering a score of 34-17.

Cowboys (-3) at Panthers

The Dallas Cowboys continue to show competitive spirit, with both analysts seeing them as favorites against the Carolina Panthers. Florio favors Dallas at 27-20, whereas Simms predicts a tighter contest, ending 31-27.

Cardinals at Colts (-7)

Both analysts expect a competitive matchup, yet Florio leans towards the Colts with a forecast of 27-17, compared to Simms’s prediction of 31-20.

Seahawks at Jaguars (-1.5)

In this matchup, Simms shows faith in the Jaguars, forecasting a solid win over the Seahawks. He predicts 34-24, while Florio is a bit more conservative with a score of 21-17 favoring the Jaguars.

Other Notable Predictions

  • Chargers vs. Dolphins: Florio sees a close game with scorelines of 27-24 for the Chargers, while Simms predicts a tighter contest at 23-20.
  • Patriots at Saints: Both analysts expect a Patriots victory, but Florio’s score prediction is 24-16, while Simms goes slightly higher at 28-17.
  • Browns at Steelers: With a rookie quarterback facing off against a seasoned team, Florio predicts a 24-14 win for the Steelers, while Simms sees a 20-13 outcome.
  • Titans at Raiders: The matchup pits Tom Brady against a struggling Titans team; Florio projects a 28-24 victory for the Raiders.
  • Bengals at Packers: The Packers are heavy favorites, and both analysts expect a similar outcome, with predictions of 34-17 from Florio and 35-20 from Simms.
  • 49ers at Buccaneers (-3): The Bucs have had a resurgence, and Florio predicts a tight match ending 31-27 for the Buccaneers, while Simms offers a slightly lower score of 24-20.
  • Lions at Chiefs (-2.5): Surprisingly, both analysts favor an upset for the Lions, with Florio predicting a score of 30-24 and Simms also favoring the Lions at 30-21.
  • Bills (-4.5) at Falcons: Florio suggests that the Bills might be vulnerable, predicting a narrow win of 23-20, while Simms has a closer game at 24-21.
  • Bears at Commanders (-4.5): In what promises to be an engaging rematch, Florio predicts a 35-27 win for the Commanders, while Simms takes a surprising turn in favor of the Bears with a score of 34-31.

Betting Strategies and Responsible Wagering

Florio often reminds his readers to “please bet responsibly, only with money that you can afford to lose.” The unpredictability of the NFL season reinforces the importance of cautious betting, as even seasoned analysts can struggle with their insights. Given the complex dynamics of teams this season, this advice rings truer than ever, particularly after last week’s lackluster results.

Objective Summary

As the NFL rolls into Week 6, the tension continues to build not only in the standings but also among bettors and analysts alike. Mike Florio and Chris Simms present their predictions on a diverse collection of matchups, featuring teams like the Eagles, Cowboys, and Packers that are looking to assert dominance heading into the mid-season.

The predictions highlight varying levels of confidence and perspectives on team performance. While Florio emphasizes the need for the Eagles to rebound and the Patriots’ playoff aspirations, Simms presents a balanced approach to the numerous unpredictable matchups that NFL fans anticipate each Sunday.

In conclusion, both analysts bring shared credibility and insight that keeps NFL followers engaged. With Week 6 upon us, fans can look forward to an intriguing mix of games, uncertainty, and more engaging narratives that the NFL consistently delivers.

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