As college football continues to heat up in Week 5 of the 2025 season, fans, analysts, and bettors alike are eagerly dissecting matchups to identify the best betting opportunities. As we delve into predictions for several intriguing games, it’s essential to consider team performance, statistical analyses, and recent trends. This week of college football promises thrilling matchups, including contests featuring Middle Tennessee State vs. Kennesaw State, Liberty vs. Old Dominion, and Alabama vs. Georgia. Let’s dive into this week’s key predictions.
Middle Tennessee State vs. Kennesaw State
Kickoff: 6 PM ET
Recent Performance & Stats:
Middle Tennessee State (MTSU) enters this game with a record of 1-3. They recently suffered a setback against Marshall, losing 42-28 at home. Despite some bright spots, including rushing for over four yards per carry, their defense has struggled, allowing 261 passing yards to Marshall.
In contrast, Kennesaw State boasts a 2-2 record, celebrating a close 28-21 win over Arkansas State. The Owls demonstrated a balanced offensive attack, stacking up nearly 500 yards of total offense, including significant contributions from quarterback Amari Odom.
The Pick:
MTSU has struggled on the road, sporting a mere 2.4 yards rushing and yielding nearly 6 yards per carry defensively. Kennesaw State’s home advantage coupled with a potent offense gives them the edge in this matchup. Expect Kennesaw to cover the spread at -7.5.
Liberty vs. Old Dominion
Kickoff: 6 PM ET
Recent Performance & Stats:
Liberty’s season has not started well, currently sitting at 1-3 after a 21-13 home loss to James Madison. Their offensive struggles are evident, with disappointing results from quarterback Ethan Vasko.
Old Dominion (ODU), on the other hand, is enjoying a healthier 2-1 mark after a resounding 45-26 victory against Virginia Tech, showcasing a dynamic offensive performance with 526 total yards.
The Pick:
Liberty’s lack of efficiency on offense, combined with ODU’s explosiveness, tilts the odds heavily in favor of the Monarchs. Liberty has not covered the spread in their last six games, while ODU seems to be the safer bet at -16.
Jacksonville State vs. Southern Miss
Kickoff: 7 PM ET
Recent Performance & Stats:
Jacksonville State’s (JSU) recent form reflects a 2-2 record, marked by a significant 45-10 victory over FCS Murray State. However, their road performance, particularly against Georgia Southern, raises questions.
Southern Miss, also at 2-2, struggled against Louisiana Tech in their last outing but has displayed resilient defensive capabilities.
The Pick:
Given Southern Miss’ strong defensive performances at home and JSU’s inconsistent play away from home, Southern Miss as the -4 favorite seems favorable.
Arizona vs. Iowa State
Kickoff: 7 PM ET
Recent Performance & Stats:
Arizona remains unbeaten at 3-0, recently defeating Kansas State with a solid ground game. In contrast, Iowa State is also enjoying a strong run at 4-0 after a win at Arkansas State.
The Pick:
Iowa State’s defensive prowess and home-field advantage make them the smart play at -6.5, especially with Arizona entering their first true road game of the season.
Virginia Tech vs. NC State
Kickoff: 7 PM ET
Recent Performance & Stats:
Virginia Tech is reeling from several disappointing performances and coaching changes, while NC State’s offense has been impressive despite their recent road loss to Duke. The Wolfpack is also well-equipped to exploit a struggling Virginia Tech defense.
The Pick:
With both teams trending in opposite directions and Virginia Tech’s defensive weaknesses, the over for this matchup at 58 seems promising.
Other Notable Matchups
Memphis vs. FAU (7 PM ET): Memphis, undefeated at 4-0, showcases an explosive offense. Play them at -13.5 due to FAU’s struggles.
Oregon vs. Penn State (7:30 PM ET): Oregon’s solid performance throughout the season places them slightly ahead against Penn State. The Ducks at +3.5 could be a tactical advantage.
Alabama vs. Georgia (7 PM ET): With both teams boasting powerful offense and defense, Georgia at -3 holds a slight advantage based on defensive metrics.
- BYU vs. Colorado (10:15 PM ET): BYU is 3-0 and has performed well; taking them at -7 seems logical with Colorado struggling against tougher opponents.
Conclusion
Week 5 of the college football season presents exciting betting opportunities. Careful consideration of team performance, statistics, and situational contexts is crucial for bettors. From Middle Tennessee State’s road woes to Old Dominion’s offensive surge, college football offers rich narratives and betting angles that make each game a thrilling experience. As we analyze these matchups, staying informed with the latest statistics and trends can aid in making educated decisions. Whether you’re a seasoned bettor or a casual fan, this week’s games promise plenty of action and excitement on the gridiron.
